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Article

A spontaneous nonhuman primate model of inherited retinal degeneration.

JCI insight - 23 Jun 2025

Yi Wei, Xu Mingming, Xue Ying, Cao Yingxue, Yang Ziqi, Zhou Lingli, Zhou Yang, Shi Le, Mai Xiaomei, Sun Zehui, Qing Wenjie, Li Yuying, Qing Aolun, Zhang Kaiwen, Ou Lechun, Chen Shoudeng, Duh Elia J, Liu Xialin

Abstract excerpt

Inherited retinal degenerations (IRDs) are important causes of progressive, irreversible blindness. Hereditary macular diseases, in particular, are significant in their effect on the specialized, central cone photoreceptor-rich macula responsible for high resolution vision. Autosomal dominant Best vitelliform macular dystrophy (BVMD), caused by variants in the BEST1 gene, is one of the most common inherited...

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Source

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Identifiers

PMID: 40327408
DOI: 10.1172/jci.insight.190807
PMCID: PMC12220943

Genes

BEST1
RPE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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