Article
Digital phenotyping evidence for the reduced positivity offset as a mechanism underlying anhedonia among individuals at clinical high-risk for psychosis.
Schizophrenia research - 1 Jul 2025
Bartolomeo Lisa A, James Sydney H, Berglund Alysia M, Raugh Ian M, Mittal Vijay A, Walker Elaine F, Strauss Gregory P
Abstract excerpt
Prior studies suggest that the "anhedonia paradox" in schizophrenia (i.e., discrepant results indicating intact hedonic reactivity despite reduced frequency of pleasure-seeking activity) can be explained by a reduction in the "positivity offset" (i.e., a reduction in the normative tendency to experience greater positive than negative affect during low arousal neutral contexts that promote reward-seeking...
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