Microbial and metabolic profiles associated with HPV infection and cervical intraepithelial neoplasia: a multi-omics study

Abstract excerpt

ABSTRACT Cervical cancer is the most common malignancy of the female reproductive system, with the incidence of human papillomavirus (HPV) being a crucial factor in its pathogenesis. Emerging evidence indicates that cervicovaginal microbiota may influence HPV persistence and cervical intraepithelial neoplasia (CIN). However, the interplay between cervicovaginal and cervical tissue microbiomes and their...