Metagenomic insight into the vaginal microbiome in women infected with HPV 16 and 18

doi:10.1038/s41522-025-00747-1

Article

Metagenomic insight into the vaginal microbiome in women infected with HPV 16 and 18

12 Jun 2025

Abstract excerpt

Human papillomavirus (HPV) 16 and 18 (HPV 16/18) account for over 70% of cervical cancer (CC) cases, yet their interaction with the vaginal microbiome (VM) remains unclear. This study explored the association between high-risk HPV types (HR-HPVs), VM composition and bacterial function using shotgun metagenomic sequencing. In early-stage cervical lesions, the HPV 16/18 group showed reduced Lactobacillus-dominant...

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