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Article

Circulating exo-miRNA-27a-5p is a novel biomarker of the tofacitinib treatment response in rheumatoid arthritis

28 Apr 2025

Abstract excerpt

BACKGROUND: Effective biological markers able to monitor the response of Janus kinase inhibitor (JAKi) are lacking. Exosomal microRNAs (exomiRNAs) can alter their expression during treatment and are ideal biomarkers for therapeutic interventions. In this study, we explored potential biomarkers for monitoring tofacitinib treatment response in patients with RA. METHODS: Peripheral blood mononuclear cells (PBMCs)...

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Share to Extracellular vesicles in disease
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PMID: 40296164
DOI: 10.1186/s41927-025-00502-1

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