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High-quality genome assembly and comparative analysis reveal extensive genomic variation in Talaromyces marneffei.

Microbial genomics - 1 Apr 2025

Luo Jinxia, Bian Jingyuan, Murillo Michaela, Hau Pak-Ting, Feng Yi, Chau Eddie Chung-Ting, Yan Yuyao, Ng Laam-Ching, Parsha Ayesha S K, Siu Gilman Kit-Hang, Chow Franklin Wang-Ngai, Xiong Qing

Abstract excerpt

Talaromyces marneffei is a dimorphic fungus that transitions from a filamentous form at 25 °C to a pathogenic yeast form at 37 °C, demonstrating pathogenicity mostly in immunocompromised individuals, such as those with human immunodeficiency virus/AIDS. Though it is one of the most severe infectious fungi in Southeast Asia, the lack of comprehensive genomic analysis has hindered advancement in strain...

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PMID: 40294122
DOI: 10.1099/mgen.0.001400
PMCID: PMC12037069

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