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Article

Exploring the role of gut microbiota in intervertebral disc degeneration: insights from bidirectional Mendelian randomization analysis.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society - 1 Jun 2025

Xiao Jiheng, Zhou Xianglong, Xia Tianyi, Zhang Weiqi, Xing Xin, Zhang Yingze, Xiong Liming

Abstract excerpt

OBJECTIVE: Although previous studies have indicated a potential association between the gut microbiota and intervertebral disc degeneration (IVDD), the precise nature of this relationship remains unclear. The objective of this study is to further explore the potential causal relationship between gut microbiota and IVDD using a bidirectional Mendelian randomization approach, with the aim of identifying potential...

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PMID: 40257470
DOI: 10.1007/s00586-025-08794-0

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