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Development of a reliable risk prognostic model for lung adenocarcinoma based on the genes related to endotheliocyte senescence

12 Apr 2025

Abstract excerpt

Cellular senescence is a hallmark for cancers, particularly in lung adenocarcinoma (LUAD). This study developed a risk model using senescence signature genes for LUAD patients. Based on the RNA-seq, clinical information and mutation data of LUAD patients collected from the TCGA and GEO database, we obtained 102 endotheliocyte senescence-related genes. The "ConsensusClusterPlus" R package was employed for...

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PMID: 40221448
DOI: 10.1038/s41598-025-95551-4

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