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Loss of Ten1 in mice induces telomere shortening and models human dyskeratosis congenita

11 Apr 2025

Abstract excerpt

Telomere length regulation is essential for genome stability as short telomeres can trigger cellular senescence and apoptosis constituting an integral aspect of biological aging. Telomere biology disorders (TBDs) such as dyskeratosis congenita (DC) are rare, inherited diseases with known mutations in at least 16 different genes encoding components of the telomere maintenance complexes. The precise role of TEN1,...

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PMID: 40215293
DOI: 10.1126/sciadv.adp8093

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