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Exploring the role of gut microbiota in colorectal liver metastasis through the gut-liver axis

13 Mar 2025

Abstract excerpt

Colorectal liver metastasis (CRLM) represents a major therapeutic challenge in colorectal cancer (CRC), with complex interactions between the gut microbiota and the liver tumor microenvironment (TME) playing a crucial role in disease progression via the gut-liver axis. The gut barrier serves as a gatekeeper, regulating microbial translocation, which influences liver colonization and metastasis. Through the...

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PMID: 40181829
DOI: 10.3389/fcell.2025.1563184

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