Article
The RSPO2 gene is associated with bilateral anterior amelia in Chihuahuas.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Sept 2025
Chevallier Lucie, Green Marin, Vo Julia, Vernau Karen, Marcellin-Little Denis J, Jagannathan Vidhya, Leeb Tosso, Bannasch Danika
Abstract excerpt
Bilateral anterior amelia (BAA) is the congenital absence of thoracic limbs and has been reported in the Chihuahua as an autosomal recessive disorder. In some cases, the digits of the pelvic limbs can be variably affected, but otherwise, the pelvic limbs are generally spared. A GWAS performed with nine BAA affected Chihuahuas identified a significant association on chromosome 13, and homozygosity mapping...
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