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Plasmid conjugation drives within-patient plasmid diversity.

Microbial genomics - 1 Mar 2025

Grayson Fan, Loman Leo, Nonnenmacher Toby, Pople Diane, Pollard Jack, Patel Bharat, Williams David, Hounsome Luke, Hopkins Katie L, Robotham Julie V, Ledda Alice

Abstract excerpt

Plasmids are well-known vehicles of antimicrobial resistance (AMR) gene dissemination. Through conjugation, plasmid-encoded AMR genes are spread among neighbouring bacteria, irrespective of their strain or even their species. This process is very concerning from a public health perspective, as plasmid-borne AMR gene outbreaks are often not confined to single species or strains and are therefore more difficult to...

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Identifiers

PMID: 40111255
DOI: 10.1099/mgen.0.001361
PMCID: PMC11925198

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