Geographic divergence of methicillin-resistant Staphylococcus aureus ST5-SCC mec I in the aftermath of a major earthquake and tsunami: impact of a plasmid harboring heavy metal resistance genes

Abstract excerpt

ABSTRACT Methicillin-resistant Staphylococcus aureus (MRSA) is a major public health menace. The global spread of MRSA is characterized by successive waves of epidemic clones dominating specific geographical regions. The acquisition of genes encoding resistance to heavy metals (HMRGs) is thought to be a key feature in the geographic divergence of MRSA. However, the cause-effect relationship between the presence...

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