Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Integrating DNA and RNA sequencing for enhanced pathogen detection in respiratory infections

14 Mar 2025

Abstract excerpt

BACKGROUND: The clinical value of shotgun metagenomic next-generation sequencing (mNGS) in improving the detection rates of respiratory pathogens is well-established. However, mNGS is complex and expensive. This study designed and evaluated the performance of targeted NGS (tNGS) in diagnosing respiratory infections. METHODS: We retrospectively included samples from 281 patients with lower respiratory tract...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibiotic Use and Resistance
Share to Gut microbiota and health
Share to Respiratory viral infections research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40087699
DOI: 10.1186/s12967-025-06342-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Integrating DNA and RNA sequencing for enhanced pathogen detection in respiratory infectionsPMID 40087699Read ↗

Enhancing lower respiratory tract infection diagnosis: implementation and clinical assessment of multiplex PCR-based and hybrid capture-based targeted next-generation sequencingSemantic proximity Read ↗

Comparative diagnostic performance of metagenomic and two targeted sequencing methods in lower respiratory infectionSemantic proximity Read ↗

Comparative performance of three next-generation sequencing techniques in real clinical lower respiratory tract infectionsSemantic proximity Read ↗

Clinical utility of metagenomic next-generation sequencing in pathogen detection for lower respiratory tract infectionsSemantic proximity Read ↗

Shotgun metagenomic sequencing analysis as a diagnostic strategy for patients with lower respiratory tract infectionsSemantic proximity Read ↗

Diagnosis value of targeted and metagenomic sequencing in respiratory tract infectionSemantic proximity Read ↗

Improving Pulmonary Infection Diagnosis with Metagenomic Next Generation SequencingSemantic proximity Read ↗

Comparative analysis of metagenomic and targeted next-generation sequencing for pathogens diagnosis in bronchoalveolar lavage fluid specimensSemantic proximity Read ↗

Comparing the diagnostic value of targeted with metagenomic next-generation sequencing in immunocompromised patients with lower respiratory tract infectionSemantic proximity Read ↗

Respiratory Tract Pathogen Detection in Children: Clinical Practice and Considerations of mNGS and tNGS TechnologiesSemantic proximity Read ↗

The significance of metagenomic next-generation sequencing and targeted next-generation sequencing in the diagnostic evaluation of patients with suspected pulmonary infectionsSemantic proximity Read ↗

Laboratory validation of a clinical metagenomic next-generation sequencing assay for respiratory virus detection and discoverySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.