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UHPLC-MS/MS-based untargeted metabolite profiling of Lyme neuroborreliosis

11 Mar 2025

Abstract excerpt

The diagnosis of Lyme neuroborreliosis (LNB) requires the demonstration of intrathecal synthesis of Borrelia antibodies in a patient's cerebrospinal fluid (CSF), which involves the invasive procedure of a lumbar puncture. This study serves as a feasibility study aimed at exploring the potential of using serum samples, which are easily obtainable routine clinical samples, for LNB diagnostics via advanced...

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PMID: 40069240
DOI: 10.1038/s41598-025-92189-0

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