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Article

Investigating whether smoking and alcohol behaviours influence risk of type 2 diabetes using a Mendelian randomisation study.

Scientific reports - 7 Mar 2025

Reed Zoe E, Sallis Hannah M, Richmond Rebecca C, Attwood Angela S, Lawlor Deborah A, Munafò Marcus R

Abstract excerpt

Previous studies suggest that smoking and higher alcohol consumption are associated with greater type 2 diabetes (T2D) risk. However, studies examining whether this reflects causal relationships are limited and often do not consider continuous glycaemic traits. We conducted both two-sample and one-sample Mendelian randomisation (MR), using publicly available GWAS data and UK Biobank data, respectively, to examine...

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Identifiers

PMID: 40055374
DOI: 10.1038/s41598-025-90437-x
PMCID: PMC11889105

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