Cross-species and mammal-to-mammal transmission of clade 2.3.4.4b highly pathogenic avian influenza A/H5N1 with PB2 adaptations.

doi:10.1038/s41467-025-57338-z

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Cross-species and mammal-to-mammal transmission of clade 2.3.4.4b highly pathogenic avian influenza A/H5N1 with PB2 adaptations.

Nature communications - 6 Mar 2025

Pardo-Roa Catalina, Nelson Martha I, Ariyama Naomi, Aguayo Carolina, Almonacid Leonardo I, Gonzalez-Reiche Ana S, Muñoz Gabriela, Ulloa Mauricio, Ávila Claudia, Navarro Carlos, Reyes Rodolfo, Castillo-Torres Pablo N, Mathieu Christian, Vergara Ricardo, González Álvaro, González Carmen Gloria, Araya Hugo, Castillo Andrés, Torres Juan Carlos, Covarrubias Paulo, Bustos Patricia, van Bakel Harm, Fernández Jorge, Fasce Rodrigo A, Johow Magdalena, Neira Víctor, Medina Rafael A

Abstract excerpt

Highly pathogenic H5N1 avian influenza viruses (HPAIV) belonging to lineage 2.3.4.4b emerged in Chile in December 2022, leading to mass mortality events in wild birds, poultry, and marine mammals and one human case. We detected HPAIV in 7,33% (714/9745) of cases between December 2022-April 2023 and sequenced 177 H5N1 virus genomes from poultry, marine mammals, a human, and wild birds spanning >3800 km of Chilean...

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PMID: 40044729
DOI: 10.1038/s41467-025-57338-z
PMCID: PMC11882949

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