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Article

Obstructive sleep apnea's causal links to depression, well-being, and negative moods: a bidirectional mendelian randomized study.

European archives of psychiatry and clinical neuroscience - 1 Mar 2026

Liao Jianhong, Gao Xiang, Fang Ting, Li Yanru, Han Demin

Abstract excerpt

Previous observational studies showed associations between obstructive sleep apnea (OSA) and depression and other negative moods. However, the causality has not been determined. Single nucleotide polymorphisms were identified as instrumental variables by screening from genome-wide association studies. Bidirectional two-sample mendelian randomization (MR) was applied to assess the potential causal relationship...

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PMID: 40025155
DOI: 10.1007/s00406-025-01969-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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