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mRNA Galsomes Vaccine Protects Budgerigars Against Virulent Chlamydia psittaci Challenge

19 Feb 2025

Abstract excerpt

Background/Objectives: Chlamydia (C.) psittaci is an avian respiratory pathogen that regularly infects budgerigars (Melopsittacus undulatus) and is a known zoonosis. This study aimed to evaluate the efficacy of a nucleoside-modified mRNA vaccine formulated in lipid nanoparticles (LNPs), either with (mRNA Galsomes) or without (mRNA LNPs) the glycolipid antigen α-Galactosylceramide, in protecting budgerigars...

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PMID: 40006752
DOI: 10.3390/vaccines13020206

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