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Syndromic and Non-Syndromic Primary Failure of Tooth Eruption: A Genetic Overview

24 Jan 2025

Abstract excerpt

Primary failure of tooth eruption (PFE) is a rare genetic disorder characterized by the failure of teeth to erupt in the absence of obvious physical obstructions, often resulting in a progressive open bite that is resistant to orthodontic treatment. While PFE can be caused by genetic or systemic factors (such as cysts, tumors, and endocrine imbalances), the non-syndromic causes are primarily genetic, with an...

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PMID: 40004475
DOI: 10.3390/genes16020147

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