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Article

A nomogram for predicting T315I-free survival in chronic phase chronic myeloid leukemia patients: a multicenter retrospective study.

Scientific reports - 18 Feb 2025

Hu Shi-Wei, Yang Xiu-di, Wu Di-Jiong, Wang Yi, Zhu Xiao-Qiong, Feng Wei-Ying, Qian Hong-Lan, Lu Ying, Chen Li-Li, Cao Li-Hong, Le Jing, Zhang Li, Shao Yan-Ping, Liu Li-Rong, Tian Guo-Yan, Zhou Hui, Chen Yu, Yin Xiu-Feng, Feng Xiao-Ning, Huang Li, Zhang Kai-Feng, Xia Yong-Ming, Xu Lin-Juan, Zhang Hui-Qi, Zhang Gang, Jia Yong-Qing, Zhou Xiu-Jie, Wu Gong-Qiang, Tu Jin-Ming, Zhu Feng, Zhang Yue-Feng, Yao Guo-Li, Zhu Jing-Jing, Tong Hong-Yan, Jin Jie, Huang Jian

Abstract excerpt

The T315I mutation poses a significant threat to patients with chronic phase chronic myeloid leukemia (CP-CML). This study aimed to establish a nomogram to predict the risk of T315I mutation in CP-CML patients. The training cohort included 1,466 patients from 24 hematology centers, and the validation cohort included 820 patients from an additional 20 centers. Peripheral blood blast (PBB), additional chromosomal...

Read the complete abstract on PubMed

Topics

Adolescent
Adult
Aged
Female

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Humans

Male

Middle Aged

Young Adult

Disease-Free Survival

Fusion Proteins, bcr-abl

Leukemia, Myelogenous, Chronic, BCR-ABL Positive

Leukemia, Myeloid, Chronic-Phase

Mutation

Nomograms

Prognosis

Retrospective Studies

ROC Curve

Source

Open in PubMed Open full text

Identifiers

PMID: 39966463
DOI: 10.1038/s41598-025-89851-y
PMCID: PMC11836442

Genes

CP
BCR

Provenance

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