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Development of a Highly Multiplexed RT-LAMP Assay for Coverage of Genetic Sequence Diversity.

Analytical chemistry - 25 Feb 2025

Gilligan-Steinberg Shane D, Kline Enos C, Wang Qin, Britton Rhett J, Kim Wookyeom, Rupp Jason W, Gu Hanwen, Beck Ingrid A, Hull Ian T, Panpradist Nuttada, Stekler Joanne D, Frenkel Lisa M, Drain Paul K, Lai James J, Lutz Barry R

Abstract excerpt

Nucleic acid amplification tests (NAATs) can achieve high accuracy for diagnosing infectious diseases by targeting conserved genetic sequences specific to the target organism. Isothermal NAATs, such as reverse-transcription loop mediated isothermal amplification (RT-LAMP), simplify instrumentation requirements, facilitating point-of-care testing. However, sequence variation due to genetic variability can cause...

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PMID: 39945656
DOI: 10.1021/acs.analchem.4c05583

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