EGFR testing practices, treatment choice and clinical outcomes in advanced NSCLC in a real-world setting: A retrospective analysis of a US-based electronic health records database.

doi:10.1016/j.lungcan.2025.108412

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Article

EGFR testing practices, treatment choice and clinical outcomes in advanced NSCLC in a real-world setting: A retrospective analysis of a US-based electronic health records database.

Lung cancer (Amsterdam, Netherlands) - 1 Mar 2025

Subramanian Janakiraman, Gregg Jeffrey, Berktas Mehmet, Li Jingyi, Leighl Natasha B

Abstract excerpt

OBJECTIVES: Guidelines recommend epidermal growth factor receptor (EGFR) mutation testing for patients with advanced non-small cell lung cancer (NSCLC) and initiation of first-line EGFR tyrosine kinase inhibitors (EGFR-TKIs) for EGFR mutation-positive (EGFRm) NSCLC. We analyzed a nationwide electronic health record-derived de-identified database to describe EGFR testing practices, treatment choice, and outcomes...

Read the complete abstract on PubMed

Topics

Humans
Carcinoma, Non-Small-Cell Lung
Lung Neoplasms
Female
Male
ErbB Receptors

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Retrospective Studies

Aged

Middle Aged

Electronic Health Records

Protein Kinase Inhibitors

Mutation

United States

Adult

Databases, Factual

Treatment Outcome

Neoplasm Staging

Aged, 80 and over

Source

Open in PubMed

Identifiers

PMID: 39933217
DOI: 10.1016/j.lungcan.2025.108412

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 22 Oct 2026.

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