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Niacinamide and its impact on stratum corneum hydration and structure

10 Feb 2025

Abstract excerpt

Niacinamide (NIA) is widely used in skincare for its favorable safety profile, anti-aging effects, and proven clinical efficacy in treating various skin conditions. However, its direct impact on the hydration and molecular organization of the stratum corneum (SC), the primary skin barrier, remains unclear. This study examines how NIA influences the SC's lipid matrix organization, soft keratin structure, and water...

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PMID: 39929949
DOI: 10.1038/s41598-025-88899-0

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