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Article

Metabolomics in juvenile idiopathic arthritis: A distinct profile in patients under methotrexate

1 Jan 2025

Abstract excerpt

• We identified a distinctive pattern of serum metabolic signatures in juvenile idiopathic arthritis patients under methotrexate therapy. • Methotrexate use is associated with a more efficient mitochondrial function. • A decreased mitochondrial metabolism was observed in polyarticular and systemic JIA subtypes, with a decrease of several acylcarnitines’ concentrations. The objective of the present study was to...

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PMID: 39879909
DOI: 10.1016/j.clinsp.2024.100522

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