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Autophagy-mediated TET2 degradation by ALV-J Env protein suppresses innate immune activation to promote viral replication

22 Jan 2025

Abstract excerpt

ABSTRACT Avian leukosis virus subgroup J (ALV-J) poses a significant threat to the poultry industry; yet, our understanding of its replication and pathogenic mechanisms is limited. The Ten-Eleven Translocation 2 (TET2) is an indispensable regulatory factor in active DNA demethylation and immune response regulation. This study reports a significant and time-dependent decrease in TET2 levels following ALV-J...

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PMID: 39840982
DOI: 10.1128/jvi.02003-24

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