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High-impact trials with genetic and -omics information focus on cancer mutations, are industry-funded, and less transparent.

Journal of clinical epidemiology - 1 Apr 2025

Russo Luigi, Siena Leonardo M, Farina Sara, Pastorino Roberta, Boccia Stefania, Ioannidis John P A

Abstract excerpt

OBJECTIVES: To assess how genetics and -omics information is used in the most cited recent clinical trials and to evaluate industry involvement and transparency patterns. STUDY DESIGN AND SETTING: This is a meta-research evaluation using a previously constructed database of the 600 most cited clinical trials published from 2019 to 2022. Trials that utilized genetic or -omics characterization of participants in...

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PMID: 39826627
DOI: 10.1016/j.jclinepi.2025.111676

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