Article
Evaluation of the Toxicity and Outcomes of the Combination of Midostaurin and CLAG-M in Patients With FLT3-Mutated Acute Myeloid Leukemia (AML): A Multicenter Retrospective Analysis.
The Annals of pharmacotherapy - 1 Aug 2025
Chen Ashley, Baek Grace, Russell Kathryn, Shaw Carole, Othus Megan, Cohen Jonathan, Palmer Shannon, Rasmussen Jack, Bubalo Joseph, Tsomo Tenzin, Schwarz Tenley, Namburi Swathi, Halpern Anna
Abstract excerpt
BACKGROUND: Addition of midostaurin to standard "7+3" (cytarabine and anthracycline) significantly prolongs overall and event-free survival. At University of Washington/Fred Hutchinson Cancer Center (UW/FHCC), the standard regimen for newly diagnosed (ND) and relapsed/refractory (R/R) AML is clad...
Topics
- Humans
- Leukemia, Myeloid, Acute
- Retrospective Studies
- Staurosporine
- fms-Like Tyrosine Kinase 3
- Male
- Female
- Middle Aged
- Antineoplastic Combined Chemotherapy Protocols
- Aged
- Adult
- Cytarabine
- Mitoxantrone