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The role of luteinizing hormone activity in spermatogenesis: from physiology to clinical practice

13 Jan 2025

Abstract excerpt

The production of spermatozoa, a process known as spermatogenesis, is primarily controlled by follicle-stimulating hormone (FSH) and luteinizing hormone (LH)-driven testosterone. LH acts on the Leydig cells, stimulating steroid production, predominantly testosterone, and activating critical inter-related spermatogenesis regulatory pathways. Despite evidence that exogenous gonadotropins containing LH activity can...

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PMID: 39800700
DOI: 10.1186/s12958-024-01333-4

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