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Activity of Platinum Chemotherapy in Men With Prostate Cancer With and Without DNA Damage Repair Mutations.

Clinical genitourinary cancer - 1 Feb 2025

Lakritz Stephanie, Nicklawsky Andrew, Alami Vida, Kohli Manish, Moskaluk Chris, Riedlinger Greg, Salhia Bodour, Singer Eric A, Naqash Abdul Rafeh, Nepple Ken, Edge Stephen, Myint Zin, Kolesar Jill, Adra Nabil, Flaig Thomas, Graham Laura S

Abstract excerpt

INTRODUCTION: Alterations in homologous recombination repair (HRR) genes occur in 20%-30% of men with metastatic castration-resistant prostate cancer (mCRPC) which may increase sensitivity to platinum chemotherapy. Specifically, exceptional responses to platinum chemotherapy have been reported among patients with BRCA mutations. This study aimed to evaluate the efficacy of platinum chemotherapy in patients with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39793235
DOI: 10.1016/j.clgc.2024.102293
PMCID: PMC12875706

Genes

BRCA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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