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Exploring the association between familial hemiplegic migraine genes (CACNA1A, ATP1A2 and SCN1A) with migraine and epilepsy: A UK Biobank exome-wide association study.

Cephalalgia : an international journal of headache - 1 Jan 2025

Staehr Christian, Nyegaard Mette, Bach Flemming W, Rohde Palle Duun, Matchkov Vladimir V

Abstract excerpt

BACKGROUND: Familial hemiplegic migraine (FHM) types 1-3 are associated with protein-altering genetic variants in CACNA1A, ATP1A2 and SCN1A, respectively. These genes have also been linked to epilepsy. Previous studies primarily focused on phenotypes, examining genetic variants in individuals with characteristic FHM symptoms. This study aimed to investigate the association of FHM genetic variation with migraine...

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Identifiers

PMID: 39781574
DOI: 10.1177/03331024241306103

Genes

SCN1A
ATP1A2
CACNA1A

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