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PDE11A Is a Phenotype Modulator of Primary Bilateral Macronodular Adrenal Hyperplasia: Results of a 334-Patient Series

3 Jan 2025

Abstract excerpt

CONTEXT: Primary bilateral macronodular adrenal hyperplasia (PBMAH), the most common cause of Cushing syndrome due to bilateral nodules, is a heterogeneous disease at the clinical, hormonal, and morphological levels. ARMC5-inactivating pathogenic variants are causative of PBMAH, and rare variants of PDE11A have been associated with PBMAH. OBJECTIVE: The aim of this study, on a large cohort of individuals with...

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Phosphodiesterase function and regulation
Pituitary Gland Disorders and Treatments
Sexual function and dysfunction studies

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39774659
DOI: 10.1210/clinem/dgae918

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