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ICAM-1 K469E gene polymorphism, genotype-phenotype correlation, and retinopathy in Type 2 diabetes mellitus patients.

Ophthalmic genetics - 1 Apr 2025

Singh Sanjana B, Ramalingam Sudha, Sankaran Ramalingam, Veronika Merlin, Mercy Janaki Jeevamala

Abstract excerpt

CONTEXT: The role of genetic factors in the development of diabetic retinopathy is evident from the fact that only 50% of patients with the non-proliferative type of diabetic retinopathy progress to proliferative diabetic retinopathy. Though the K469E polymorphism of the ICAM-1 (Intercellular Adhesion Molecule-1) gene is known to increase the risk of developing Diabetic Retinopathy (DR) among Type 2 diabetic...

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Identifiers

PMID: 39763306
DOI: 10.1080/13816810.2024.2447498

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