Article
A Novel Protein NLRP12‐119aa that Prevents Rhabdovirus Replication by Disrupting the RNP Complex Formation
4 Jan 2025
Abstract excerpt
The accurate assembly of the ribonucleoprotein (RNP) complex is fundamental for the replication and transcription of rhabdoviruses, which are known for their broad pathogenic impact. A novel 119-amino-acid protein, NLRP12-119aa is identified, encoded by the circular RNA circNLRP12, that effectively disrupts the formation of rhabdovirus RNP complexes through two distinct mechanisms and significantly reduces their...
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