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The relationship between mitochondrial health, telomerase activity and longitudinal telomere attrition, considering the role of chronic stress

30 Dec 2024

Abstract excerpt

Telomere attrition is a hallmark of biological aging, contributing to cellular replicative senescence. However, few studies have examined the determinants of telomere attrition in vivo in humans. Mitochondrial Health Index (MHI), a composite marker integrating mitochondrial energy-transformation capacity and content, may be one important mediator of telomere attrition, as it could impact telomerase activity, a...

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Share to Genetics, Aging, and Longevity in Model Organisms
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PMID: 39738205
DOI: 10.1038/s41598-024-77279-9

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