Emergence and genetic characterization of KLUC-3 extended-spectrum β-lactamase-producing Escherichia coli ST95 High-Risk clone causing nosocomial infection in Japan.

Abstract excerpt

OBJECTIVES: KLUC β-lactamase is a minor extended-spectrum β-lactamase (ESBL) derived from chromosome-encoded cefotaximase in Kluyvera cryocrescens. This study aimed to characterize the genetic context of KLUC-3-producing Escherichia coli and blaKLUC-3-harboring plasmids and assess nosocomial transmission. METHODS: In a national genomic surveillance conducted in 2019 and 2020, KLUC-3-producing E. coli strains...

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