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Article

Genomic analyses revealed low genetic variation in the intron-exon boundary of the doublesex gene within the natural populations of An. gambiae s.l. in Burkina Faso.

BMC genomics - 18 Dec 2024

Kientega Mahamadi, Morianou Ioanna, Traoré Nouhoun, Kranjc Nace, Kaboré Honorine, Zongo Odette N, Millogo Abdoul-Azize, Epopa Patric Stephane, Yao Franck A, Belem Adrien M G, Austin Burt, Diabaté Abdoulaye

Abstract excerpt

BACKGROUND: The recent success of a population control gene drive targeting the doublesex gene in Anopheles gambiae paved the way for developing self-sustaining and self-limiting genetic control strategies targeting the sex determination pathway to reduce and/or distort the reproductive capacity of insect vectors. However, targeting these genes for genetic control requires a better understanding of their genetic...

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PMID: 39695373
DOI: 10.1186/s12864-024-11127-y
PMCID: PMC11657786

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