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The role of gut microbiota and metabolomic pathways in modulating the efficacy of SSRIs for major depressive disorder

18 Dec 2024

Abstract excerpt

This study aims to explore the mechanism by which gut microbiota influences the antidepressant effects of serotonin reuptake inhibitors (SSRIs) through metabolic pathways. A total of 126 patients were analyzed for their gut microbiota and metabolomics. Patients received SSRI treatment and were categorized into responder and non-responder groups based on changes in their Hamilton Depression Rating Scale (HAMD-17)...

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PMID: 39695082
DOI: 10.1038/s41398-024-03208-z

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