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Case report: Modified transplantation for pediatric patients with pyruvate kinase deficiency.

Frontiers in immunology - 1 Jan 2024

Pang Yuhui, Qi Xiaoyu, Qin Jiayue, Zhai Xiaoran, Wang Rongxiao, Cao Jianzhu, Zhang Na, Liu Jinxia, Li Jianying, Wu Weihai, Wei Shanshan, Zhang Jingjing, Zhang Shaofei, Zhang Yaochen, Yue Yan

Abstract excerpt

Pyruvate kinase deficiency (PKD) is an autosomal recessive genetic disease caused by mutations in the PKLR gene. To date, the clinical manifestations of PKD are heterogeneous, ranging from fetal anemia, neonatal jaundice, and severe chronic hemolytic anemia to fully compensated hemolytic anemia. Successful cases of allogeneic hematopoietic stem cell transplantation (allo-HSCT) for PKD have been reported, however,...

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Share to Anemia, Hemolytic, Congenital Nonspherocytic
Share to Child, Preschool

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hematopoietic Stem Cell Transplantation

Share to Infant

Share to Pyruvate Kinase

Share to Transplantation Conditioning

Share to Transplantation, Homologous

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Identifiers

PMID: 39635530
DOI: 10.3389/fimmu.2024.1493398
PMCID: PMC11614771

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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