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Re-envisioning genetic predisposition to childhood and adolescent cancers.

Nature reviews. Cancer - 1 Feb 2025

Kratz Christian P

Abstract excerpt

Although cancer is rare in children and adolescents, it remains a leading cause of death within this age range, and genetic predisposition is the main known risk factor. Since the discovery of retinoblastoma-predisposing RB1 pathogenic germline variants in 1985, several additional high-penetrance cancer predisposition genes (CPGs) have been identified. Although few clinically recognizable genetic conditions...

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PMID: 39627375
DOI: 10.1038/s41568-024-00775-7

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RB1

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