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Infection of Helicobacter pylori contributes to the progression of gastric cancer through ferroptosis

2 Dec 2024

Abstract excerpt

Helicobacter pylori (H. pylori) is a gram-negative pathogen that colonizes gastric epithelial cells, and its chronic infection is the primary risk factor for the development of gastric cancer (GC). Ferroptosis is an iron-dependent form of cell death characterized by intracellular lipid peroxide accumulation and reactive oxygen species (ROS) imbalance. There is evidence suggesting that pathogens can manipulate...

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PMID: 39622791
DOI: 10.1038/s41420-024-02253-3

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