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Article

Successful eculizumab treatment as an adjunctive therapy to desensitization in ABO-incompatible living donor kidney transplantation and its molecular phenotypes.

Frontiers in immunology - 1 Jan 2024

Heo Ga Young, Jung Minsun, Piao Honglin, Kim Hyun Jeong, Kim Hyung Woo, Lee Juhan, Huh Kyu Ha, Kim Beom Seok, Yang Jaeseok

Abstract excerpt

Introduction: ABO-incompatible (ABOi) kidney transplantation (KT) has become an important option to overcome organ shortage. Plasmapheresis/rituximab-based desensitization therapy has successfully reduced anti-ABO antibody levels and suppressed antibody-mediated rejection (AMR) in ABOi KT. However, high titers of anti-ABO antibodies in some patients are refractory to standard desensitization, leading to loss of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39530089
DOI: 10.3389/fimmu.2024.1465851
PMCID: PMC11550984

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