Estimation of Jacquard's genetic identity coefficients with bi-allelic variants by constrained least-squares.

Abstract excerpt

The Jacquard genetic identity coefficients are of fundamental importance in relatedness research. We address the estimation of these coefficients as well as other relationship parameters that derive from them such as kinship and inbreeding coefficients using a concise matrix framework. Estimation of the Jacquard coefficients via likelihood methods and the expectation-maximization algorithm is computationally very...

Topics

• Least-Squares Analysis
• Models, Genetic
• Alleles
• Algorithms
• Computer Simulation
• Gene Frequency
• Genetic Variation
• Humans
• Likelihood Functions