Article
A canonical protein complex controls immune homeostasis and multipathogen resistance.
Science (New York, N.Y.) - 20 Dec 2024
Wu Yue, Xu Weiying, Zhao Guoyan, Lei Ziyao, Li Kui, Liu Jiyun, Huang Shijia, Wang Junli, Zhong Xiangbin, Yin Xin, Wang Yuandong, Zhang Haochen, He Yang, Ye Zian, Meng Yonggang, Chang Xiaoyu, Lin Hui, Wang Xin, Gao Yuanyuan, Chai Jijie, Parker Jane E, Deng Yiwen, Zhang Yu, Gao Mingjun, He Zuhua
Abstract excerpt
The calcium (Ca2+) sensor ROD1 (RESISTANCE OF RICE TO DISEASES1) is a master regulator of immunity in rice. By screening suppressors of rod1 mutants, we show that ROD1 governs immune homeostasis by surveilling the activation of a canonical immune pathway. Mutations in OsTIR (TIR-only protein), OsEDS1 (enhanced disease susceptibility 1), OsPAD4 (phytoalexin deficient 4), and OsADR1 (activated disease resistance 1)...
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