A microarray-based IgE-molecular mimicry index (IgE-MMI): A biomarker for disease severity, clinical phenotypes, and therapeutic response in atopic dermatitis?

doi:10.1111/all.16377

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A microarray-based IgE-molecular mimicry index (IgE-MMI): A biomarker for disease severity, clinical phenotypes, and therapeutic response in atopic dermatitis?

Allergy - 1 Dec 2024

Scala Enrico, Madonna Stefania, Abeni Damiano, Cecchi Lorenzo, Cocuroccia Barbara, Dattolo Anna, Moretta Gaia, Provini Alessia, Russo Filomena, Sordi Donatella, Pallotta Sabatino, Galluzzo Marco, Talamonti Marina, Villella Valeria, Giani Mauro, Caprini Elisabetta, Albanesi Cristina, Villalta Danilo, Asero Riccardo, Matricardi Paolo Maria

Abstract excerpt

BACKGROUND: The role of autoimmune IgE responses in atopic dermatitis (AD) is highly debated. While IgE targeting self-proteins has been extensively studied, IgE responses induced by human-homologous exogenous molecular allergens (HEMAs) remains less understood. AIM: To investigate whether IgE antibody responses to HEMAs are associated with AD, its severity, and response to dupilumab. METHODS: We enrolled 3325...

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PMID: 39495073
DOI: 10.1111/all.16377

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