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Identification of a novel SNP mutation causing drop-out alleles in a paternity test using combined nest and touch-down PCR with Sanger sequencing.

Annals of human biology - 1 Feb 2024

Wang Hongbo, Shi Botong, Guo Liang, Zou Yingnan, Liu Bo, Yao Jun, Wang Baojie, Wang Zhengdong, Li Xin, Mu Gang, Ren Fu

Abstract excerpt

BACKGROUND: Short tandem repeat (STR) markers are widely used in forensic DNA analysis due to their ability to provide automated and standardised typing. However, incorrect STR typing can have a significant impact on forensic outcomes. AIM: In this study, we detected drop-out alleles at the SE33 locus in a putative father-son pair using the Microreader™ 28 A ID System. This result could lead to a false conclusion...

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PMID: 39494978
DOI: 10.1080/03014460.2024.2418591

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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