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Article

Optimal first-line treatment for EGFR-mutated NSCLC: a comparative analysis of osimertinib and second-generation EGFR-TKIs.

BMC pulmonary medicine - 16 Oct 2024

Chen Hsu-Yuan, Chen Chia-Hung, Liao Wei-Chih, Lin Yu-Chao, Chen Hung-Jen, Hsia Te-Chun, Cheng Wen-Chien, Tu Chih-Yen

Abstract excerpt

BACKGROUND: Osimertinib is an irreversible third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI). It is the preferred first-line treatment for EGFR-mutated non-small cell lung cancer (NSCLC) compared to first-generation EGFR-TKIs. However, limited research has compared its clinical effectiveness with second-generation (2nd G) EGFR-TKIs. MATERIALS AND METHODS: This study...

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Identifiers

PMID: 39415161
DOI: 10.1186/s12890-024-03336-8
PMCID: PMC11481380

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