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Discovery and synthesis of leaderless bacteriocins from the Actinomycetota

15 Oct 2024

Abstract excerpt

ABSTRACT Leaderless bacteriocins are a unique class of bacteriocins that possess antimicrobial activity after translation and have few cases of documented resistance. Aureocin A53 and lacticin Q are considered two of the most well-studied leaderless bacteriocins. Here, we used in silico genome mining to search for novel aureocin A53-like leaderless bacteriocins in GenBank and MGnify. We identified 757 core...

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PMID: 39404462
DOI: 10.1128/jb.00298-24

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