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Article

Denosumab stimulates spermatogenesis in infertile men with preserved Sertoli cell capacity

1 Oct 2024

Abstract excerpt

Sperm production depends on proper Sertoli-germ cell interaction, and we hypothesized that receptor activator of nuclear factor κB ligand (RANKL) activity in Sertoli cells may influence spermatogenesis. Treatment with the RANKL inhibitor denosumab, normally used to treat osteoporosis, increased testicular weight, inhibin B, and germ cell proliferation in ex vivo testis cultures and in vivo in a humanized RANKL...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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PMID: 39383870
DOI: 10.1016/j.xcrm.2024.101783

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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