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Evaluation of a DNA vaccine with self-designed CpG sequences against J genotype IHNV infection in rainbow trout (Oncorhynchus mykiss).

Fish & shellfish immunology - 1 Nov 2024

Zhao Li, Wu Di, Wang Jing, Wu Kaixing, Ren Yuhong, Liu Qin, Bao Endong, Shao Shuai

Abstract excerpt

Rainbow trout suffer from infectious hematopoietic necrosis virus (IHNV) outbreaks, which lead to massive mortality and huge economic loss worldwide. The approved commercial vaccine is used for the prevention of IHN in Canada. Given that Chinese domestic J-genotype isolates are different from North American IHNV isolates, the development of an effective DNA vaccine against Chinese J-genotype isolates is urgent....

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PMID: 39370023
DOI: 10.1016/j.fsi.2024.109942

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